Metabolism of cholesta-4,7-dien-3-one and cholesta-4,6-dien-3-one by mouse liver microsomes

Metabolism of Cholesta-4,7-dien-3-one and Cholesta-4,6-dien-3-one by Mouse Liver Microsomes.

The administration to rats of cholesta-3:5-dien-7-one.

The fact that cholesta-3:5-dien-7-one occurs in arteriosclerotic aorta and some other tissues, in small amounts (Hardegger, Ruzicka & Tagmann, 1943; Prelog, Ruzicka & Stein, 1943), and that it is not necessarily an artifact (Kantiengar & Morton, 1955a) makes it desirable to study the effect of administering it to animals. In the present work it has been given to rats orally at the rate of 25 mg...

24-Methyl­lanosta-7,25-dien-3-one

THE TITLE COMPOUND [SYSTEMATIC NAME: 17-(5,6-di-methyl-hept-6-en-2-yl)-4,4,10,13,14-penta-methyl-1,5,6,10,11,12,13,15,16,17-deca-hydro-2H-cyclo-penta-[α]phenanthren-3(4H,9H,14H)-one], C(31)H(50)O, is a triterpenoid which was isolated from Skimmia laureola. The three six-membered rings adopt chair, slightly distorted half-chair and distorted boat conformations, and the five-membered ring is in a...

5α-Pregna-1,20-dien-3-one

The title compound, C(21)H(30)O, was isolated from the soft coral Sinularia sp. The mol-ecule contains four alicyclic rings, all trans-fused, among which three six-membered rings are in different distorted chair conformations while a five-membered ring assumes an envelope form.

(E,E)-1,5-Di-2-thienylpenta-1,4-dien-3-one

In the title compound, C(13)H(10)OS(2), the dihedral angle between the thio-phene rings is 14.3 (1)°. The mol-ecular structure is stabilized by C-H⋯π inter-actions between a thio-phene H atom and an adjacent thio-phene ring, and by inter-molecular C-H⋯O hydrogen bonds.